8WEA: Human L-type voltage-gated calcium channel Cav1.2 (Class II) in the presence of pinaverium at 3.2 Angstrom resolution

PDB ID: 8WEADownload
MMDB ID: 239588
PDB Deposition Date: 2023/9/17
Updated in MMDB: 2023/12
Experimental Method:
electron microscopy
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 8WEA: dimeric; determined by author
Molecular Components in 8WEA
Label Count Molecule
Proteins (2 molecules)
1
Voltage-dependent L-type Calcium Channel Subunit Alpha-1c
(Gene symbol: CACNA1C)
Molecule annotation
1
Voltage-dependent Calcium Channel Subunit Alpha-2/delta-1
(Gene symbol: CACNA2D1)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
15
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
CALCIUM IONCALCIUM ION
3
1
(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
4
1
4-[(2-bromanyl-4,5-dimethoxy-phenyl)methyl]-4-[2-[2-[(1~{R},2~{S},5~{R})-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]ethoxy]ethyl]morpholin-4-ium4-[(2-bromanyl-4,5-dimethoxy-phenyl)methyl]-4-[2-[2-[(1~{R},2~{S},5~{R})-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]ethoxy]ethyl]morpholin-4-ium
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303