8WE8: Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and pinaverium at 2.9 Angstrom resolution

PDB ID: 8WE8Download
MMDB ID: 239586
PDB Deposition Date: 2023/9/17
Updated in MMDB: 2023/12
Experimental Method:
electron microscopy
Resolution: 2.9  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 8WE8: tetrameric; determined by author
Molecular Components in 8WE8
Label Count Molecule
Proteins (4 molecules)
1
Voltage-dependent L-type Calcium Channel Subunit Alpha-1c
Molecule annotation
1
Voltage-dependent Calcium Channel Subunit Alpha-2/delta-1
Molecule annotation
1
Voltage-dependent L-type Calcium Channel Subunit Beta-3
Molecule annotation
1
Calciseptin
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
16
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
CALCIUM IONCALCIUM ION
3
5
CHOLESTEROLCHOLESTEROL
4
1
[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate
5
1
1,2-Distearoyl-sn-glycerophosphoethanolamine1,2-Distearoyl-sn-glycerophosphoethanolamine
6
1
amlodipineamlodipine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303