8WE6: Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution

PDB ID: 8WE6Download
MMDB ID: 239584
PDB Deposition Date: 2023/9/17
Updated in MMDB: 2023/12
Experimental Method:
electron microscopy
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8WE6: trimeric; determined by author
Molecular Components in 8WE6
Label Count Molecule
Proteins (3 molecules)
1
Voltage-dependent L-type Calcium Channel Subunit Alpha-1c
(Gene symbol: CACNA1C)
Molecule annotation
1
Voltage-dependent Calcium Channel Subunit Alpha-2/delta-1
(Gene symbol: CACNA2D1)
Molecule annotation
1
Voltage-dependent L-type Calcium Channel Subunit Beta-3
(Gene symbol: CACNB3)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
16
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
CALCIUM IONCALCIUM ION
3
1
1,2-Distearoyl-sn-glycerophosphoethanolamine1,2-Distearoyl-sn-glycerophosphoethanolamine
4
4
CHOLESTEROLCHOLESTEROL
5
1
[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303