8WDK: The complex structure of Cul2-VCB-Protac-Wee1

PDB ID: 8WDKDownload
MMDB ID: 252482
PDB Deposition Date: 2023/9/15
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.64  Å
Source Organism:
Similar Structures:
Biological Unit for 8WDK: hexameric; determined by author and by software
Molecular Components in 8WDK
Label Count Molecule
Proteins (6 molecules)
1
Cullin-2
(Gene symbol: CUL2)
Molecule annotation
1
E3 Ubiquitin-protein Ligase Rbx1, N-terminally Processed
(Gene symbol: RBX1)
Molecule annotation
1
VON Hippel-lindau Disease Tumor Suppressor
(Gene symbol: VHL)
Molecule annotation
1
Elongin-b
(Gene symbol: ELOB)
Molecule annotation
1
Elongin-c
(Gene symbol: ELOC)
Molecule annotation
1
Wee1-like Protein Kinase
(Gene symbol: WEE1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[4-[4-[4-[[3-oxidanylidene-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]-2-prop-2-enyl-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]piperazin-1-yl]butoxy]propanoylamino]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide(2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[4-[4-[4-[[3-oxidanylidene-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]-2-prop-2-enyl-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]piperazin-1-yl]butoxy]propanoylamino]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303