8W8L: Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-38

PDB ID: 8W8LDownload
MMDB ID: 251804
PDB Deposition Date: 2023/9/3
Updated in MMDB: 2025/09
Experimental Method:
x-ray diffraction
Resolution: 1.824  Å
Source Organism:
Similar Structures:
Biological Unit for 8W8L: dimeric; determined by author and by software (PISA)
Molecular Components in 8W8L
Label Count Molecule
Proteins (2 molecules)
2
Proline--trna Ligase
(Gene symbol: proS)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
2
(2~{S})-~{N}-[5-(4-azanyl-8-fluoranyl-quinazolin-7-yl)-2-fluoranyl-phenyl]sulfonylpyrrolidine-2-carboxamide(2~{S})-~{N}-[5-(4-azanyl-8-fluoranyl-quinazolin-7-yl)-2-fluoranyl-phenyl]sulfonylpyrrolidine-2-carboxamide
2
3
SULFATE IONSULFATE ION
3
9
MAGNESIUM IONMAGNESIUM ION
4
12
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303