8W8B: Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex

PDB ID: 8W8BDownload
MMDB ID: 238934
PDB Deposition Date: 2023/9/1
Updated in MMDB: 2023/11
Experimental Method:
electron microscopy
Resolution: 3  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8W8B: pentameric; determined by author
Molecular Components in 8W8B
Label Count Molecule
Proteins (5 molecules)
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Antibody Fragment Scfv16
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Soluble Cytochrome B562,5-hydroxytryptamine Receptor 1A
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
5
CHOLESTEROLCHOLESTEROL
2
1
PALMITIC ACIDPALMITIC ACID
3
1
1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303