8W7E: Design, synthesis and biological evaluations of novel small molecular hyper-activators of human caseinolytic peptidase P (hClpP)

PDB ID: 8W7EDownload
MMDB ID: 251796
PDB Deposition Date: 2023/8/30
Updated in MMDB: 2024/09
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 8W7E: 14-meric; determined by author and by software (PISA)
Molecular Components in 8W7E
Label Count Molecule
Proteins (14 molecules)
14
Atp-dependent CLP Protease Proteolytic Subunit, Mitochondrial
(Gene symbol: CLPP)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
14
3-[(3-chlorophenyl)methyl]-6-[(4-chlorophenyl)methyl]-2,4-dihydro-1H-pyrido[2,3-c][2,7]naphthyridin-5-one3-[(3-chlorophenyl)methyl]-6-[(4-chlorophenyl)methyl]-2,4-dihydro-1H-pyrido[2,3-c][2,7]naphthyridin-5-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303