8W3D: TAS-120 covalent structure with FGFR2 molecular brake mutant

PDB ID: 8W3DDownload
MMDB ID: 257468
PDB Deposition Date: 2024/2/22
Updated in MMDB: 2025/04
Experimental Method:
x-ray diffraction
Resolution: 2.04  Å
Source Organism:
Similar Structures:
Biological Unit for 8W3D: monomeric; determined by author
Molecular Components in 8W3D
Label Count Molecule
Protein (1 molecule)
1
Fibroblast Growth Factor Receptor 2
(Gene symbol: FGFR2)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one
2
1
GLYCEROLGLYCEROL
3
3
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303