8VLB: Crystal structure of EloBC-VHL-CDO1 complex bound to compound 4 molecular glue

PDB ID: 8VLBDownload
MMDB ID: 244130
PDB Deposition Date: 2024/1/11
Updated in MMDB: 2025/12
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8VLB: tetrameric; determined by author
Molecular Components in 8VLB
Label Count Molecule
Proteins (4 molecules)
1
VON Hippel-lindau Disease Tumor Suppressor
(Gene symbol: VHL)
Molecule annotation
1
Elongin-b
(Gene symbol: ELOB)
Molecule annotation
1
Elongin-c
(Gene symbol: ELOC)
Molecule annotation
1
Cysteine Dioxygenase Type 1
(Gene symbol: CDO1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamideN-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide
2
1
CITRIC ACIDCITRIC ACID
3
1
FE (II) IONFE (II) ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303