8VHF: Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982

PDB ID: 8VHFDownload
MMDB ID: 254167
PDB Deposition Date: 2024/1/1
Updated in MMDB: 2024/11
Experimental Method:
electron microscopy
Resolution: 3.51  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8VHF: pentameric; determined by author
Molecular Components in 8VHF
Label Count Molecule
Proteins (5 molecules)
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1, Hibit
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nanobody35
Molecule annotation
1
Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short
Molecule annotation
1
Soluble Cytochrome B562,glucose-dependent Insulinotropic Receptor,lgbit
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303