8VGQ: CryoEM structure of GNE-1952-alkylated KRAS G12C in complex with engineered conformationally rigid Fab 2H11.4DS

PDB ID: 8VGQDownload
MMDB ID: 254166
PDB Deposition Date: 2023/12/27
Updated in MMDB: 2024/11
Experimental Method:
electron microscopy
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 8VGQ: trimeric; determined by author
Molecular Components in 8VGQ
Label Count Molecule
Proteins (3 molecules)
1
Gtpase Kras
(Gene symbol: KRAS)
Molecule annotation
1
FAB 2h11.4ds Heavy Chain
Molecule annotation
1
FAB 2h11.4ds Light Chain
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
Unknown
2
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
3
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303