8VEW: Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 24

PDB ID: 8VEWDownload
MMDB ID: 245938
PDB Deposition Date: 2023/12/20
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.69  Å
Source Organism:
Similar Structures:
Biological Unit for 8VEW: dimeric; determined by author and by software (PISA)
Molecular Components in 8VEW
Label Count Molecule
Proteins (2 molecules)
1
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
1
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
5'-DEOXY-5'-METHYLTHIOADENOSINE5'-DEOXY-5'-METHYLTHIOADENOSINE
2
1
5'-DEOXY-5'-METHYLTHIOADENOSINE5'-DEOXY-5'-METHYLTHIOADENOSINE
3
1
GLYCEROLGLYCEROL
4
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303