8V80: Alpha7-nicotinic acetylcholine receptor bound to epibatidine and (-)-TQS

PDB ID: 8V80Download
MMDB ID: 243119
PDB Deposition Date: 2023/12/4
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.34  Å
Source Organism:
Similar Structures:
Biological Unit for 8V80: pentameric; determined by author
Molecular Components in 8V80
Label Count Molecule
Proteins (5 molecules)
5
Neuronal Acetylcholine Receptor Subunit Alpha-7,soluble Cytochrome B562
(Gene symbol: CHRNA7)
Molecule annotation
Chemicals and Non-standard biopolymers (60 molecules)
1
25
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
5
beta-D-mannopyranosebeta-D-mannopyranose
3
5
CALCIUM IONCALCIUM ION
4
10
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
5
5
(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
6
5
EPIBATIDINEEPIBATIDINE
7
5
(3aR,4S,9bS)-4-(naphthalen-1-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide(3aR,4S,9bS)-4-(naphthalen-1-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303