8V6U: 5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking

PDB ID: 8V6UDownload
MMDB ID: 247675
PDB Deposition Date: 2023/12/3
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 8V6U: pentameric; determined by author
Molecular Components in 8V6U
Label Count Molecule
Proteins (5 molecules)
1
5-hydroxytryptamine Receptor 2A
(Gene symbol: HTR2A)
Molecule annotation
1
G Protein Alpha-subunit Q (Gi2-mini-gq Chimera)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
(Gene symbol: GNB1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
(Gene symbol: GNG2)
Molecule annotation
1
Single-chain Variable Fragment 16 (Scfv16)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303