8UXE: Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210

PDB ID: 8UXEDownload
MMDB ID: 238912
PDB Deposition Date: 2023/11/9
Updated in MMDB: 2024/11
Experimental Method:
electron microscopy
Resolution: 3.53  Å
Source Organism:
Similar Structures:
Biological Unit for 8UXE: octameric; determined by author
Molecular Components in 8UXE
Label Count Molecule
Proteins (8 molecules)
4
Peptidyl-prolyl Cis-trans Isomerase Fkbp1b
(Gene symbol: FKBP1B)
Molecule annotation
4
Ryanodine Receptor 2
(Gene symbol: RYR2)
Molecule annotation
Chemicals and Non-standard biopolymers (16 molecules)
1
4
ZINC IONZINC ION
2
8
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
3
4
4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303