8UWR: Crystal structure of human ACVR1 (ALK2) kinase in complex with compound 3

PDB ID: 8UWRDownload
MMDB ID: 254579
PDB Deposition Date: 2023/11/7
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2.04  Å
Source Organism:
Similar Structures:
Biological Unit for 8UWR: monomeric; determined by author
Molecular Components in 8UWR
Label Count Molecule
Protein (1 molecule)
1
Activin Receptor Type-1
(Gene symbol: ACVR1)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
6
SULFATE IONSULFATE ION
2
1
cyclopropyl(4-{(8R)-6-[4-(piperazin-1-yl)phenyl]pyrrolo[1,2-b]pyridazin-4-yl}piperazin-1-yl)methanonecyclopropyl(4-{(8R)-6-[4-(piperazin-1-yl)phenyl]pyrrolo[1,2-b]pyridazin-4-yl}piperazin-1-yl)methanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303