8UWL: 5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)

PDB ID: 8UWLDownload
MMDB ID: 247671
PDB Deposition Date: 2023/11/6
Updated in MMDB: 2024/07
Experimental Method:
electron microscopy
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 8UWL: pentameric; determined by author and by software
Molecular Components in 8UWL
Label Count Molecule
Proteins (5 molecules)
1
5-hydroxytryptamine Receptor 2A
(Gene symbol: HTR2A)
Molecule annotation
1
G Protein Subunit Q (Gi2-mini-gq Chimera)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
(Gene symbol: GNB1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
(Gene symbol: GNG2)
Molecule annotation
1
Single-chain Variable Fragment 16 (Scfv16)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]ureaN,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303