8UVQ: Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/down)

PDB ID: 8UVQDownload
MMDB ID: 251289
PDB Deposition Date: 2023/11/3
Updated in MMDB: 2024/08
Experimental Method:
electron microscopy
Resolution: 3.42  Å
Source Organism:
Similar Structures:
Biological Unit for 8UVQ: hexameric; determined by author
Molecular Components in 8UVQ
Label Count Molecule
Proteins (6 molecules)
6
Transitional Endoplasmic Reticulum Atpase
(Gene symbol: VCP)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
12
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
2
6
2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303