8UV2: Human p97/VCP structure with a triazole inhibitor (NSC799462/hexamer)

PDB ID: 8UV2Download
MMDB ID: 251286
PDB Deposition Date: 2023/11/2
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.23  Å
Source Organism:
Similar Structures:
Biological Unit for 8UV2: hexameric; determined by author and by software
Molecular Components in 8UV2
Label Count Molecule
Proteins (6 molecules)
6
Transitional Endoplasmic Reticulum Atpase
(Gene symbol: VCP)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
12
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
2
6
3-(4-{[(4P)-5-{[(1R)-cyclohex-2-en-1-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,6-difluorophenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate3-(4-{[(4P)-5-{[(1R)-cyclohex-2-en-1-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,6-difluorophenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303