8UOJ: Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with azepane (R)-#50 small molecule inhibitor

PDB ID: 8UOJDownload
MMDB ID: 254571
PDB Deposition Date: 2023/10/19
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8UOJ: monomeric; determined by author
Molecular Components in 8UOJ
Label Count Molecule
Protein (1 molecule)
1
Map/microtubule Affinity-regulating Kinase 3
(Gene symbol: MARK3)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
1
(6M)-4-{[(2R)-azepan-2-yl]methyl}-6-[(4R)-imidazo[1,2-a]pyridin-3-yl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one(6M)-4-{[(2R)-azepan-2-yl]methyl}-6-[(4R)-imidazo[1,2-a]pyridin-3-yl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
2
5
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
CHLORIDE IONCHLORIDE ION
4
1
BENZOIC ACIDBENZOIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303