8UOI: Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with small molecule inhibitor #65

PDB ID: 8UOIDownload
MMDB ID: 253918
PDB Deposition Date: 2023/10/19
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 8UOI: monomeric; determined by author
Molecular Components in 8UOI
Label Count Molecule
Protein (1 molecule)
1
Map/microtubule Affinity-regulating Kinase 3
(Gene symbol: MARK3)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
(7M)-7-[(4S)-imidazo[1,2-b]pyridazin-3-yl]-1-[(1R)-1-phenylethyl]-3-(piperazin-1-yl)pyrido[3,4-b]pyrazin-2(1H)-one(7M)-7-[(4S)-imidazo[1,2-b]pyridazin-3-yl]-1-[(1R)-1-phenylethyl]-3-(piperazin-1-yl)pyrido[3,4-b]pyrazin-2(1H)-one
2
5
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303