8UOH: Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with small molecule inhibitor #10

PDB ID: 8UOHDownload
MMDB ID: 253917
PDB Deposition Date: 2023/10/19
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 8UOH: dimeric; determined by author
Molecular Components in 8UOH
Label Count Molecule
Proteins (2 molecules)
2
Map/microtubule Affinity-regulating Kinase 3
(Gene symbol: MARK3)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
9
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
NICKEL (II) IONNICKEL (II) ION
3
1
(6P)-6-[(4S)-imidazo[1,2-a]pyridin-3-yl]-4-[(1R)-1-phenylethyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one(6P)-6-[(4S)-imidazo[1,2-a]pyridin-3-yl]-4-[(1R)-1-phenylethyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303