8UAK: Crystal structure of the catalytic domain of human PKC alpha (D463N, V568I, S657E) in complex with Darovasertib (NVP-LXS196) at 2.82-A resolution

PDB ID: 8UAKDownload
MMDB ID: 241825
PDB Deposition Date: 2023/9/21
Updated in MMDB: 2024/02
Experimental Method:
x-ray diffraction
Resolution: 2.82  Å
Source Organism:
Similar Structures:
Biological Unit for 8UAK: monomeric; determined by author and by software (PISA)
Molecular Components in 8UAK
Label Count Molecule
Protein (1 molecule)
1
Protein Kinase C Alpha Type
(Gene symbol: PRKCA)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(6M)-3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide(6M)-3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303