8U8A: Cryo-EM structure of LRRK2 bound to type II inhibitor ponatinib

PDB ID: 8U8ADownload
MMDB ID: 242132
PDB Deposition Date: 2023/9/16
Updated in MMDB: 2024/02
Experimental Method:
electron microscopy
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 8U8A: dimeric; determined by author
Molecular Components in 8U8A
Label Count Molecule
Proteins (2 molecules)
2
Leucine-rich Repeat Serine/threonine-protein Kinase 2
(Gene symbol: LRRK2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide
2
2
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303