8U7X: Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with inhibitor compound 24

PDB ID: 8U7XDownload
MMDB ID: 240895
PDB Deposition Date: 2023/9/15
Updated in MMDB: 2024/01
Experimental Method:
x-ray diffraction
Resolution: 2.06  Å
Source Organism:
Similar Structures:
Biological Unit for 8U7X: monomeric; determined by software (PISA)
Molecular Components in 8U7X
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Phosphatase Non-receptor Type 11
(Gene symbol: PTPN11)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(3S,4S)-8-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrido[2,3-b]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine(3S,4S)-8-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrido[2,3-b]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303