8U6S: Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(3-morpholino-3-oxopropoxy)phenoxy)indolizine-2-carbonitrile (JLJ757), a non-nucleoside inhibitor

PDB ID: 8U6SDownload
MMDB ID: 238353
PDB Deposition Date: 2023/9/13
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.99  Å
Source Organism:
Similar Structures:
Biological Unit for 8U6S: dimeric; determined by author and by software (PISA)
Molecular Components in 8U6S
Label Count Molecule
Proteins (2 molecules)
1
Reverse Transcriptase/ribonuclease H
(Gene symbol: gag-pol)
Molecule annotation
1
P51 RT
(Gene symbol: gag-pol)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
(4S)-8-{2-[3-(morpholin-4-yl)-3-oxopropoxy]phenoxy}indolizine-2-carbonitrile(4S)-8-{2-[3-(morpholin-4-yl)-3-oxopropoxy]phenoxy}indolizine-2-carbonitrile
2
2
PHOSPHATE IONPHOSPHATE ION
3
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303