8U6I: Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(2-((2-cyanoindolizin-8-yl)oxy)phenoxy)ethyl)-N-methylacrylamide (JLJ745), a non-nucleoside inhibitor

PDB ID: 8U6IDownload
MMDB ID: 238343
PDB Deposition Date: 2023/9/13
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.46  Å
Source Organism:
Similar Structures:
Biological Unit for 8U6I: dimeric; determined by author and by software (PISA)
Molecular Components in 8U6I
Label Count Molecule
Proteins (2 molecules)
1
Reverse Transcriptase/ribonuclease H
(Gene symbol: gag-pol)
Molecule annotation
1
P51 RT
(Gene symbol: gag-pol)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
N-[2-(2-{[(4R)-2-cyanoindolizin-8-yl]oxy}phenoxy)ethyl]-N-methylpropanamideN-[2-(2-{[(4R)-2-cyanoindolizin-8-yl]oxy}phenoxy)ethyl]-N-methylpropanamide
2
3
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303