8U4W: The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor

PDB ID: 8U4WDownload
MMDB ID: 244703
PDB Deposition Date: 2023/9/11
Updated in MMDB: 2024/07
Experimental Method:
x-ray diffraction
Resolution: 3.02  Å
Source Organism:
Similar Structures:
Biological Unit for 8U4W: monomeric; determined by author
Molecular Components in 8U4W
Label Count Molecule
Protein (1 molecule)
1
Poly [adp-ribose] Polymerase 1, Processed C-terminus
(Gene symbol: PARP1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
(4M)-4-(2-{4-[(3S)-1-acetylpiperidine-3-carbonyl]piperazine-1-carbonyl}-1-benzofuran-7-yl)-1H-isoindol-1-one(4M)-4-(2-{4-[(3S)-1-acetylpiperidine-3-carbonyl]piperazine-1-carbonyl}-1-benzofuran-7-yl)-1H-isoindol-1-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303