8TZX: Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1

PDB ID: 8TZXDownload
MMDB ID: 249584
PDB Deposition Date: 2023/8/28
Updated in MMDB: 2024/07
Experimental Method:
x-ray diffraction
Resolution: 3.15  Å
Source Organism:
Similar Structures:
Biological Unit for 8TZX: trimeric; determined by author
Molecular Components in 8TZX
Label Count Molecule
Proteins (3 molecules)
1
Protein Cereblon
(Gene symbol: CRBN)
Molecule annotation
1
DNA Damage-binding Protein 1
(Gene symbol: DDB1)
Molecule annotation
1
Protein WIZ
(Gene symbol: WIZ)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
ZINC IONZINC ION
2
1
(3S)-3-(5-{(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione(3S)-3-(5-{(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3
2
SULFATE IONSULFATE ION
4
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303