8TZH: Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant)

PDB ID: 8TZHDownload
MMDB ID: 239526
PDB Deposition Date: 2023/8/26
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 3.9  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8TZH: dimeric; determined by author
Molecular Components in 8TZH
Label Count Molecule
Proteins (2 molecules)
1
E11 Darpin
Molecule annotation
1
Leucine-rich Repeat Serine/threonine-protein Kinase 2
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
(2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine(2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine
2
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303