8TYQ: Structure of the C-terminal half of LRRK2 bound to GZD-824 (G2019S mutant)

PDB ID: 8TYQDownload
MMDB ID: 239520
PDB Deposition Date: 2023/8/25
Updated in MMDB: 2023/12
Experimental Method:
electron microscopy
Resolution: 2.99  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8TYQ: dimeric; determined by author
Molecular Components in 8TYQ
Label Count Molecule
Proteins (2 molecules)
1
Leucine-rich Repeat Serine/threonine-protein Kinase 2
Molecule annotation
1
Designed Ankyrin Repeats Protein E11
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303