8TXY: X-ray crystal structure of JRD-SIK1/2i-3 bound to a MARK2-SIK2 chimera

PDB ID: 8TXYDownload
MMDB ID: 241114
PDB Deposition Date: 2023/8/24
Updated in MMDB: 2024/01
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8TXY: monomeric; determined by author
Molecular Components in 8TXY
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Mark2
(Gene symbol: MARK2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
2
1
N-[(5P,8R)-5-(2-cyano-5-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamideN-[(5P,8R)-5-(2-cyano-5-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
3
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303