8TVT: Structure of human Cysteine desulfurase Nfs1 with L-propargylglycine bound to active site PLP in complex with ISD11, Acp1 and ISCU2

PDB ID: 8TVTDownload
MMDB ID: 252130
PDB Deposition Date: 2023/8/18
Updated in MMDB: 2025/09
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 8TVT: tetrameric; determined by author
Molecular Components in 8TVT
Label Count Molecule
Proteins (4 molecules)
1
Cysteine Desulfurase
Molecule annotation
1
LYR Motif-containing Protein 4
Molecule annotation
1
Acyl Carrier Protein
Molecule annotation
1
Iron-sulfur Cluster Assembly Enzyme Iscu
Molecule annotation
Chemicals and Non-standard biopolymers (52 molecules)
1
30
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
PYRIDOXAL-5'-PHOSPHATEPYRIDOXAL-5'-PHOSPHATE
3
1
L-PropargylglycineL-Propargylglycine
4
3
GLYCEROLGLYCEROL
5
8
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
6
2
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
7
1
2,5,8,11,14,17-HEXAOXANONADECAN-19-OL2,5,8,11,14,17-HEXAOXANONADECAN-19-OL
8
1
2,3-DIHYDROXY-1,4-DITHIOBUTANE2,3-DIHYDROXY-1,4-DITHIOBUTANE
9
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
10
1
{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
11
1
S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioateS-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate
12
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
13
1
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303