8TRB: Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist JNJ47965567

PDB ID: 8TRBDownload
MMDB ID: 253595
PDB Deposition Date: 2023/8/9
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.36  Å
Source Organism:
Similar Structures:
Biological Unit for 8TRB: trimeric; determined by author
Molecular Components in 8TRB
Label Count Molecule
Proteins (3 molecules)
3
P2X Purinoceptor 7
Molecule annotation
Chemicals and Non-standard biopolymers (34 molecules)
1
3
N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamideN-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide
2
3
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
3
6
ZINC IONZINC ION
4
6
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
5
15
PALMITIC ACIDPALMITIC ACID
6
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303