8TRA: Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160

PDB ID: 8TRADownload
MMDB ID: 253594
PDB Deposition Date: 2023/8/9
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.41  Å
Source Organism:
Similar Structures:
Biological Unit for 8TRA: trimeric; determined by author
Molecular Components in 8TRA
Label Count Molecule
Proteins (3 molecules)
3
P2X Purinoceptor 7
(Gene symbol: P2rx7)
Molecule annotation
Chemicals and Non-standard biopolymers (34 molecules)
1
3
N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamideN-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamide
2
3
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
3
6
ZINC IONZINC ION
4
6
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
5
15
PALMITIC ACIDPALMITIC ACID
6
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303