8TQS: Complex of human thrombin (S195A) bound to a bivalent inhibitor comprised of DNA Aptamer HD22 conjugated to Dabigatran with a linker

PDB ID: 8TQSDownload
MMDB ID: 246183
PDB Deposition Date: 2023/8/8
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.207  Å
Source Organism:
Similar Structures:
Biological Unit for 8TQS: trimeric; determined by author and by software
Molecular Components in 8TQS
Label Count Molecule
Proteins (2 molecules)
1
Thrombin Heavy Chain
(Gene symbol: F2)
Molecule annotation
1
Prothrombin
(Gene symbol: F2)
Molecule annotation
Nucleotide(1 molecule)
1
DNA (30-mer)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
MAGNESIUM IONMAGNESIUM ION
2
1
SODIUM IONSODIUM ION
3
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
4
1
N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanineN-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine
5
1
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303