8TM7: Human NAMPT in complex with substrate NAM and small molecule activator NP-A3

PDB ID: 8TM7Download
MMDB ID: 248219
PDB Deposition Date: 2023/7/28
Updated in MMDB: 2024/06
Experimental Method:
x-ray diffraction
Resolution: 1.79  Å
Source Organism:
Similar Structures:
Biological Unit for 8TM7: dimeric; determined by author and by software (PISA)
Molecular Components in 8TM7
Label Count Molecule
Proteins (2 molecules)
2
Nicotinamide Phosphoribosyltransferase
(Gene symbol: NAMPT)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
2
GLYCEROLGLYCEROL
2
2
NICOTINAMIDENICOTINAMIDE
3
2
N-{2-[(4R)-2,2-dimethyl-4-(propan-2-yl)oxan-4-yl]ethyl}-N-[(4-methoxyphenyl)methyl]furan-2-carboxamideN-{2-[(4R)-2,2-dimethyl-4-(propan-2-yl)oxan-4-yl]ethyl}-N-[(4-methoxyphenyl)methyl]furan-2-carboxamide
4
3
CHLORIDE IONCHLORIDE ION
5
2
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303