8TLR: Crystal Structure of human HRAS G12C covalently bound to AMG 510

PDB ID: 8TLRDownload
MMDB ID: 250415
PDB Deposition Date: 2023/7/27
Updated in MMDB: 2024/09
Experimental Method:
x-ray diffraction
Resolution: 1.70004  Å
Source Organism:
Similar Structures:
Biological Unit for 8TLR: monomeric; determined by author
Molecular Components in 8TLR
Label Count Molecule
Protein (1 molecule)
1
Gtpase Hras
(Gene symbol: HRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
2
1
AMG 510 (bound form)AMG 510 (bound form)
3
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303