8THR: Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation

PDB ID: 8THRDownload
MMDB ID: 237283
PDB Deposition Date: 2023/7/17
Updated in MMDB: 2023/10
Experimental Method:
electron microscopy
Resolution: 3.12  Å
Source Organism:
Similar Structures:
Biological Unit for 8THR: monomeric; determined by author and by software
Molecular Components in 8THR
Label Count Molecule
Protein (1 molecule)
1
Fluorescent Protein Mvenus,synaptic Vesicular Amine Transporter,gfp Nano Body,synaptic Vesicular Amine Transporter,synaptic Vesicular Amine Transporter
(Gene symbol: SLC18A2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one(3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303