8TF0: Crystal structure of Grp94 N-terminal domain bound to the purine inhibitor PU-H36

PDB ID: 8TF0Download
MMDB ID: 254547
PDB Deposition Date: 2023/7/7
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2.79  Å
Source Organism:
Similar Structures:
Biological Unit for 8TF0: monomeric; determined by author
Molecular Components in 8TF0
Label Count Molecule
Protein (1 molecule)
1
Endoplasmin
(Gene symbol: HSP90B1)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
3
MAGNESIUM IONMAGNESIUM ION
2
1
9-(pent-4-yn-1-yl)-8-[(2,4,6-trimethylphenyl)sulfanyl]-9H-purin-6-amine9-(pent-4-yn-1-yl)-8-[(2,4,6-trimethylphenyl)sulfanyl]-9H-purin-6-amine
3
1
GLYCEROLGLYCEROL
4
6
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303