8TBT: Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator Compound 2

PDB ID: 8TBTDownload
MMDB ID: 240684
PDB Deposition Date: 2023/6/29
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.34  Å
Source Organism:
Similar Structures:
Biological Unit for 8TBT: tetrameric; determined by author and by software (PISA)
Molecular Components in 8TBT
Label Count Molecule
Proteins (4 molecules)
4
Pyruvate Kinase Pklr
(Gene symbol: PKLR)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
4
1,6-di-O-phosphono-beta-D-fructofuranose1,6-di-O-phosphono-beta-D-fructofuranose
2
4
PYRUVIC ACIDPYRUVIC ACID
3
4
MANGANESE (II) IONMANGANESE (II) ION
4
4
POTASSIUM IONPOTASSIUM ION
5
2
{6-[(3-methoxyphenyl)methyl]-4-methyl-5-oxo-5,6-dihydro-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-2-yl}(methyl)sulfaniumolate{6-[(3-methoxyphenyl)methyl]-4-methyl-5-oxo-5,6-dihydro-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-2-yl}(methyl)sulfaniumolate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303