8TA2: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42

PDB ID: 8TA2Download
MMDB ID: 242109
PDB Deposition Date: 2023/6/26
Updated in MMDB: 2025/06
Experimental Method:
electron microscopy
Resolution: 2.74  Å
Source Organism:
Similar Structures:
Biological Unit for 8TA2: dimeric; determined by author
Molecular Components in 8TA2
Label Count Molecule
Proteins (2 molecules)
2
Chloride Channel Protein 2
(Gene symbol: CLCN2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid
2
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303