8T7Q: Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

PDB ID: 8T7QDownload
MMDB ID: 236693
PDB Deposition Date: 2023/6/21
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8T7Q: monomeric; determined by author
Molecular Components in 8T7Q
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Phosphatase Non-receptor Type 11
(Gene symbol: PTPN11)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303