8T5B: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor EKC-110

PDB ID: 8T5BDownload
MMDB ID: 248561
PDB Deposition Date: 2023/6/12
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.08  Å
Source Organism:
Similar Structures:
Biological Unit for 8T5B: tetrameric; determined by author and by software
Molecular Components in 8T5B
Label Count Molecule
Proteins (4 molecules)
2
Integrase
(Gene symbol: gag-pol)
Molecule annotation
2
Integrase
(Gene symbol: gag-pol)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
(2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid(2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid
2
2
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303