8T1F: Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047

PDB ID: 8T1FDownload
MMDB ID: 232572
PDB Deposition Date: 2023/6/2
Updated in MMDB: 2023/07
Experimental Method:
electron microscopy
Resolution: 3.49  Å
Source Organism:
Similar Structures:
Biological Unit for 8T1F: tetrameric; determined by author
Molecular Components in 8T1F
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 4/enhanced Green Fluorescent Protein Chimera
(Gene symbol: TRPV4)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
4
2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
2
4
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303