8T1E: Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD

PDB ID: 8T1EDownload
MMDB ID: 232571
PDB Deposition Date: 2023/6/2
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.77  Å
Source Organism:
Similar Structures:
Biological Unit for 8T1E: tetrameric; determined by author
Molecular Components in 8T1E
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 4,enhanced Green Fluorescent Protein
(Gene symbol: TRPV4)
Molecule annotation
Chemicals and Non-standard biopolymers (43 molecules)
1
32
[(2~{R})-2-[(~{Z})-hexadec-9-enoyl]oxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (~{Z})-docos-13-enoate[(2~{R})-2-[(~{Z})-hexadec-9-enoyl]oxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (~{Z})-docos-13-enoate
2
8
(2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside(2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside
3
3
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303