8T1D: Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD

PDB ID: 8T1DDownload
MMDB ID: 232570
PDB Deposition Date: 2023/6/2
Updated in MMDB: 2023/07
Experimental Method:
electron microscopy
Resolution: 3.35  Å
Source Organism:
Similar Structures:
Biological Unit for 8T1D: tetrameric; determined by author
Molecular Components in 8T1D
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily V Member 4/enhanced Green Fluorescent Protein Chimera
(Gene symbol: TRPV4)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303