8SZF: Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid nanodiscs

PDB ID: 8SZFDownload
MMDB ID: 242396
PDB Deposition Date: 2023/5/29
Updated in MMDB: 2024/03
Experimental Method:
electron microscopy
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 8SZF: dimeric; determined by author
Molecular Components in 8SZF
Label Count Molecule
Proteins (2 molecules)
1
Extracellular Calcium-sensing Receptor
(Gene symbol: CASR)
Molecule annotation
1
Extracellular Calcium-sensing Receptor
(Gene symbol: CASR)
Molecule annotation
Chemicals and Non-standard biopolymers (22 molecules)
1
11
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
TRYPTOPHANTRYPTOPHAN
3
4
CALCIUM IONCALCIUM ION
4
2
PHOSPHATE IONPHOSPHATE ION
5
2
N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amineN-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
6
1
SPERMINESPERMINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303