8SVP: Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-278

PDB ID: 8SVPDownload
MMDB ID: 247021
PDB Deposition Date: 2023/5/17
Updated in MMDB: 2024/06
Experimental Method:
x-ray diffraction
Resolution: 3.32  Å
Source Organism:
Similar Structures:
Biological Unit for 8SVP: dimeric; determined by author and by software (PISA)
Molecular Components in 8SVP
Label Count Molecule
Proteins (2 molecules)
2
Pregnane X Receptor Ligand Binding Domain Fused to Src-1 Coactivator Peptide
(Gene symbol: NR1I2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
(1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide(1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
2
2
(1P)-N-(5-tert-butyl-2-{[(3R)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide(1P)-N-(5-tert-butyl-2-{[(3R)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303