8STP: Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) varient in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor

PDB ID: 8STPDownload
MMDB ID: 239247
PDB Deposition Date: 2023/5/11
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 3.09  Å
Source Organism:
Similar Structures:
Biological Unit for 8STP: dimeric; determined by author and by software (PISA)
Molecular Components in 8STP
Label Count Molecule
Proteins (2 molecules)
1
Reverse Transcriptase/ribonuclease H
(Gene symbol: gag-pol)
Molecule annotation
1
P51 RT
(Gene symbol: gag-pol)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}indolizine-2-carbonitrile8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}indolizine-2-carbonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303